WAH MEK / RESEARCH / PRINCIPLE
The One-One Principle
Why WAH MEK changes one relevant mechanism at a time so correction response is easier to interpret.
PRINCIPLE
One mechanism. One correction. One interpretable test.
Changing several interventions at once makes it harder to know what produced the observed response. The One-One Principle keeps the test narrow: one proposed mechanism, one targeted correction, one exposure, and one comparable retest before the next evidence-authorized decision.
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